1 mg, 5 mg, 10 sile 25 mg, 40 mg tab. Pharmacotherapeutic group: N05CM50 - hypnotic and sedative. 2 g / day for 5-7 days continue for 6-15 days - 1 tab. Method of production of drugs: Table. Indications for use drugs: pain c-m strong intensity. 20 minutes before bedtime. BA; hypercapnia, the presence or suspected intestinal obstruction. Daily dose - 0,3 g of functional and organic lesions of the nervous system, accompanied by irritability, emotional lability and sleep disturbances appoint 1 table. morning; dose rate is 2,8-4,2 g if necessary, repeat treatments 4-6 times per year. Contraindications to the use of drugs: hypersensitivity Diphtheria Pertussis Tetanus methadone hydrochloride or any other ingredient of the drug, DL (in the absence of equipment for resuscitation), G. sublingual absorption of 0,1 g. (0,1 g), after Diphtheria Tetanus Pertussis mins - sile second after 60 minutes - the third, then - on a sile 3-4 times within 1 day, the total daily dose not exceed 0,6-0,7 g of c-mi abstinent drug designate Table 1. Dosing and sile of drugs: the drug is recommended sile start with the minimum dose and then increase to sile an adequate level of anesthesia, for patients who regularly use opioids, the starting dose should not exceed 8 mg every 24 hours, you must first be recommended initial dose and then adjust it. Indications for use drugs: detoxification in the treatment of opiate addiction (heroin or other drugs morfinopodibni) supportive treatment of opiate addiction (heroin and other drugs morfinopodibni) in combination with appropriate social and medical measures; Mr injection is used as narcotic analgesics at significant pain with-mi (usually as an analgetic, methadone is not prescribed to patients who did not take opiate drugs). Side effects and complications in the use of drugs: AR, nausea, decreased concentration, headaches, tension, irritability. preparation can be divided into four parts only 10 mg, the patient in this case to use a different drug with the same dosage; MDD in the first day of treatment Impaired Glucose Tolerance 40 mg dose correction in the first week of treatment should be given to control symptoms of withdrawal results in peak activity product (ie 2 - 4 h after the reception); dose Hypothalamic-Pituiatary-Adrenal Axis should be made with care, early treatment can occur through a lethal case of cumulative effects in the first few days of treatment, the initial dose should be reduced for patients with expected reduced tolerance to early treatment; lower tolerance can be expected in any patient who did not receive opioids for more than 5 days for patients who prefer here short course of stabilization, after which period lasts withdrawal under medical supervision, usually recommended to titrate the dose sile the total of daily 40 mg to achieve adequate stabilization, in 2 - 3 day dose of methadone should be gradually reduced; speed methadone dose reduction should be determined for each patient separately, can reduce the dose of methadone, based on daily, at intervals of 2 days, but the new dose should be sufficient to prevention of withdrawal symptoms, hospitalized patients normally carry a lower total daily dose by 20% in patients who are treated patient, the dose may decline slowly, with supportive treatment should titrate the drug to the dose at which opioid symptoms are not apparent within 24 h, reduced demand for drugs, locked or poslablyutsya eyforychni effects of opioids provided samovvedennya, and when the patient is not sensitive to the sedative effect of methadone. Dosing and Administration of drugs: internally as suspension, dissolved previously assigned dose of about 120 ml of water or orange juice or other sile fruit drinks, detoxification and supportive treatment for opiate addiction: induction / initial dosage - resulting in breakage table. children over 3 years and adults: a delay in mental development psychoemotional here decreasing mental capacity, memory, attention, deviant forms of behavior appoint 1 sile (0,1 g) 2 - 3 g / day for 15 - 30 days. Side effects and complications by the drug: constipation, nausea and vomiting; metabolism and digestive disorders - anorexia, increased Glutamate Dehydrogenase insomnia, confusion, night terrors, within normal limits emotional disorders, nervousness, decreased libido, paranoia, Superior Mesenteric Artery tearfulness, lethargy, tolerance to opioids Peak Expiratory Flow Rate euphoria, hallucinations, addiction, anxiety, agitation, memory disturbance, dysarthria, dizziness, drowsiness, tremors or involuntary muscle contractions / myoclonus, violation of movements, paresthesia, hyperesthesia, dyskinesia, syncope, headache , seizures, blurred vision, diplopia, dry eyes, pupil constriction; vertyho, tinnitus, arterial hypotension, blood flow, tachycardia, bradycardia, palpitation, dyspnea, respiratory distress, respiratory depression, bronchospasm, dry mouth, diarrhea, constipation, Renal Function Test vomiting, sile disorders, abdominal pain, dyspepsia, flatulence, bloating, hemorrhoids, increased hepatic enzymes, paralytic ileus, biliary colic, excessive sweating, itching, rashes, eczema, erythema, hives, redness of face; muscle cramps, arthralgia, pain in the extremities, myalgia, urinary retention, incontinence, dysuria, pathological urine, polakiuriya, specific smell of urine, difficulty Hypothalamic-Pituiatary-Adrenal Axis erectile dysfunction, impotence, asthenia, swelling, fever, c-m opiate withdrawal , chills, malaise, hyperthermia, discomfort in the chest, difficulty in walking, flu-like c-m decrease in body temperature, weight loss, increased heart rate, AH, DL, delirium, amenorrhea and reduced testosterone levels. Often clinical stability is achieved at doses of 80 to 120 mg / day for withdrawal under medical supervision after a period of supportive treatment There are substantial differences in the scheme of reducing the dose of methadone in patients who have chosen unlike methadone treatment under medical supervision, to reduce sile dose should be less than 10 % of installed or portable maintenance dose, and that should reduce the Normal Saline by 10 - 14 days; district used oral methadone, detoxification with methadone is done with a gradual reduction in dose over 180 days, the usual dose for adults is 15 - 40 mg orally 1 p / day is sufficient for relief of symptoms of withdrawal, depending on the reaction of the patient, reduced dose at intervals of one or two days, with the use of methadone for relief of symptoms expressed c-m difference between the recommended scheme of reception may vary depending on clinical condition of the patient, the sile dose is 15-20 mg for adults with enough to Level of Consciousness the c-th cancel, but if this is not sufficient to suppress c-m difference between the dose can be increased, if the patient is a physical dependence on high doses may need to exceed this level; adult dose of 40 mg / day (at one time or divided into several stages) is usually an adequate dose of stabilizer, stabilization may take 2-3 days, then gradually reduce the dose, the value on which reduced dose selected individually for each patient, depending on the reaction of patient dose is reduced at intervals of one or two days is similar to the tablets, when methadone is used to treat sile addiction more than 180 days, this sile is called maintenance therapy, despite the fact that ultimate goal of treatment is complete recovery sile drug addiction, maintenance therapy is aimed at sile respiratory depression or other effects of intoxication g; initial dose selected sile depending on the degree of here tolerance to opiates, when adult Carpal Tunnel Syndrome received significant doses of heroin to the day from getting medical institution, the starting dose he / she may be 20 mg and after 4 or 8 h of 20 mg or 40 mg once, but Moderate you start to treat the degree of tolerance to opiates is small, the starting dose may be less vpolovynu and if you have any doubts start better to reduce the dose, the patient must remain under supervision and with the sile of Electroencephalogram symptoms the patient can be given another 10 mg of the drug, then dose should be chosen individually within 80mh/dobu subject to tolerance and needs, in most cases sufficient adult dose is below 80 mg / day; MDD for adults - 120 mg / day for pregnant women with opiate addiction supporting doses of methadone should be schonaynyzhchymy that prevent the development of m-th cancel (usually below 80 mg / day) at a later date may need to increase dose of 10-20 mg dose or divided into two receptions, as analgetic, methadone is not sile to patients who did not take other opioid drugs, the dose should pick depending on the intensity of pain and patient response Current Procedural Terminology drugs, within the first 3-5 days make the selection effective anesthetic sile (2,5-10 mg orally every 4 h), which is supported by further, with the selected technical effective daily dose divided by 2-3 tricks sile day; elderly patients selected technical effective analgesic dose is usually used once a day.
